10th HBV RESEARCH SYMPOSIUM

INVITATION

I am very happy to have an opportunity to invite our leading colleagues to the 10th Korea-Japan-Taiwan HBV Research Symposium in Seoul, April 26-28, 2024.

On behalf of the organizing committee, we heartily welcome the HBV researchers from Taiwan, Japan, and Korea to share the cutting-edge progress in your research and stimulate the spirit of collaboration for the advancement of our understanding of our formidable, yet intriguing foe.

Since the birth of this meeting in 2013 under the outstanding leadership of founding scholars, the HBV Research Symposium has greatly contributed to the academic friendship of the participants. This year, we are deeply grateful for being able to hold the first HBV Research Symposium in Korea. I look forward to meeting all our dear friends, both old and new, in the vibrant city of Seoul.

With deep gratitude,


Jin-Wook Kim, M.D., Ph.D.
President,
The 10th Korea-Japan-Taiwan HBV Research Symposium
Professor, Department of Medicine,
Seoul National University College of Medicine

CHAIRMAN OF THE ORGANIZING COMMITTEE

  • Hyung Joon YimKorea Univ., Korea

  • Kyun-Hwan KimSungkyunkwan Univ., Korea

  • Yasuhito TanakaKumamoto Univ., Japan

  • Chun-Jen LiuNational Taiwan Univ., Taiwan

  • Sang Hoon AhnYonsei Univ., Korea

SCIENTIFIC PROGRAM

16:00-18:30
Group Tour (Changgyeong Palace: 185, Changgyeonggung-ro, Jongno-gu, Seoul, Korea)
18:30-20:30
Welcome Reception (Lee Kun-Hee Auditorium: Cancer Research Institute)
08:30-09:00
Registration
09:00-09:10
Opening Remarks
Jin-Wook Kim (Korea), Hyung Joon Yim (Korea)
09:10-09:25
Welcome Remarks
Yasuhito Tanaka (Japan), Chun-Jen Liu (Taiwan), Sang Hoon Ahn (Korea)
09:25-10:25
Session 1. HBV Integration and HBx
Pei-Jer Chen (Taiwan), Jin-Wook Kim (Korea)
09:25-09:40
HBx Mutations Developed during Antiviral Therapy
Chau-Ting Yeh (Taiwan)
09:40-09:55
HBV DNA Integration Provides a DNA Biomarker for Subgrouping HBV-Driven HCC and Monitoring Residual HCC after Curative Therapies
Shiou-Hwei Yeh (Taiwan)
09:55-10:10
The Role of N6-methyladenosine (m6A) RNA Methylation in the Hepatitis B Virus Life Cycle
Geon-Woo Kim (Korea)
10:10-10:25
The Structural Study of the HBV x Protein (HBx)
Shinichi Machida (Japan)
10:25-10:50
Coffee Break
10:50-12:20
Session 2. Preclinical Targets and Therapies for Chronic Hepatitis B
Yasuhito Tanaka (Japan), Kyun-Hwan Kim (Korea)
10:50-11:05
Targeting KIF4 as a Novel Anti-HBV Entry Inhibitor
Abdullah Mahmoud (Japan)
11:05-11:20
Identification of Novel Compounds as Potent Inhibitors of HBV Entry by Modeling-Based Fitting of NTCP Empty Pockets
Kyun-Hwan Kim (Korea)
11:20-11:35
A Small Molecule iCDM-34 Identified by in Silico Screening Suppresses HBV DNA through Activation of Aryl Hydrocarbon Receptor
Yutaka Furutani (Japan)
11:35-11:50
Targeting Capsid-Forming Ability of HBV Core Protein with Small-Molecule Inhibitors
Chunkyu Ko (Korea)
11:50-12:05
The Role of an Innovative Therapeutics SAG-524 in HBV-RNA Destabilization
Yasuhito Tanaka (Japan)
12:05-12:20
Sirtuin 2 Inhibitors Suppress HBV Replication
Kyongmin Kim (Korea)
12:20-13:00
Lunch
13:00-13:30
Poster Viewing
 
13:30-13:55
Special Lecture I
Sang Hoon Ahn (Korea)
13:30-13:55
Clinical Role and Significance of Glycan in HBV Infection
Masashi Mizokami (Japan)
13:55-15:25
Session 3. Clinical View
Chun-Jen Liu (Taiwan), Hyung Jun Yim (Korea)
13:55-14:10
Using GAAD Score for Prediction of the Development of HCC in HBV-Related Cirrhosis Patients
Tung-Hung Su (Taiwan)
14:10-14:25
The Association with iTACT-HBcrAg and HCC Risk after HBsAg Seroprevalence
Tetsuya Hosaka (Japan)
14:25-14:40
Enhancing Functional Cure: Retreating Off-Nuc Clinical Relapse with Pegylated Interferon
Wen-Juei Jeng (Taiwan)
14:40-14:55
HBsAg Decline Related to Immune Checkpoint Inhibitors in Cancer Patients
Yi-Hsiang Huang (Taiwan)
14:55-15:10
Changes of Lipid loading Capacity of Lipoproteins in Chronic Hepatitis B Patients Switching from TDF to TAF
Pin-Nan Cheng (Taiwan)
15:10-15:25
Recent Prevalence and Characteristics of Patients with Hepatitis Delta Virus in Japan
Naoya Sakamoto (Japan)
15:25-15:50
Coffee Break
15:50-16:15
Special Lecture II
Masamichi Muramatsu (Japan)
15:50-16:15
Control of Hepatitis B: A Successful Example of Scientific, Medical and Public Communities
Pei-Jer Chen (Taiwan)
16:15-17:30
Session 4. Molecular Virology
Chau-Ting Yeh (Taiwan), Koichi Watashi (Japan)
16:15-16:30
Tripartite Motif-Containing Protein 21 Regulates Hepatocyte Nuclear Factors, Thereby Contributes to IFN-γ-Induced Suppression of HBV
Juhee Won (Korea)
16:30-16:45
Why Macaque-Derived NTCP Cannot Function as an HBV Receptor?
Kaho Shionoya (Japan)
16:45-17:00
TRIM26 Supports HBV Replication by Preventing Core Protein from Proteasome-Dependent Degradation
Yuki Nakaya (Japan)
17:00-17:15
Epitranscriptomic Cytidine Methylation of the Hepatitis B Viral RNA Packaging Signal Is Essential for Viral Reverse Transcription
Kevin Tsai (Taiwan)
17:15-17:30
Alteration of Gene Expression after Entecavir and Pegylated Interferon Therapy in HBV-Infected Chimeric Mouse Liver
Masataka Tsuge (Japan)
17:30-17:45
Examination of Lipid Nanoparticles Loading Ribonucleoprotein-Oligonucleotide Complexes for Genome Editing to Hepatitis B Virus Inhibition in Vitro and in Vivo
Kyoko Tsukiyama-Kohara (Japan)
18:30-20:30
Welcome Dinner - Social Hour: Seoulgaon
* We will provide transportation for all participants to the dinner venue. Please utilize the provided coach service (round trip).
08:30-09:00
Registration
09:00-10:30
Session 5. Immunology
Masanori Isogawa (Japan), Eui-Cheol Shin (Korea)
09:00-09:15
HBV-Specific Tissue-Resident Memory T Cells in Human HBV-Infected Liver Diseases
Yang Cheng (Taiwan)
09:15-09:30
Liver Sinusoidal T Cells in Healthy and HBV-Infected Livers
Eui-Cheol Shin (Korea)
09:30-09:45
Selection of Viral Escape Mutants by CD8+ T Cells in HBeAg-Negative Chronic Hepatitis B Patients
Hung-Chih Yang (Taiwan)
09:45-10:00
Direct Analysis of Human Hepatic Stellate Cells by Flow Cytometry
Hideki Ueno (Japan)
10:00-10:15
Distinct NK-like Liver Sinusoidal CD56hiCD8+CD161- T Cells Expanded in Patient with HBV Infection
June-Young Koh (Korea)
10:15-10:30
Strategic Direction: Alliance to Combating Vertical Transmission of Hepatitis B in Tanzania – Mobilizing Support from Asia to Africa
Jin Yong Kim (Korea)
10:30-10:40
Closing Remark
Pei-Jer Chen (Taiwan), Jin-Wook Kim (Korea)
PE-01
Functional Region in preS1 for Forming a Stable Complex with NTCP
Chisa Kobayashi (Japan)
PE-02
Inhibitory Activity of Sterol Derivatives against HBV Entry and Its Mechanism
Atsuto Kusunoki (Japan)
PE-03
Development of a Novel Liver-Immune Organoid Model to Reproduce the HBV Infected Liver Microenvironment
Daichi Akuzawa (Japan)
PE-04
Mapping of Amino Acid Region in NTCP Involved in the Interaction with HBV preS1
Kayo Matsuzawa (Japan)
PE-05
Role of Lipid Droplet Accumulation in HBV-HCC Development
Ryuta Ueda (Japan)
PE-06
Decreased Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Treated with Besifovir
Seong Hee Kang (Korea)
PE-07
Effects of Tenofovir Disoproxil Fumarate versus Tenofovir Alafenamide on Risk of Osteoporotic Fracture in Patients with Chronic Hepatitis B
Eunju Kim (Korea)
PE-08
Strong Cross-Neutralizing Antibodies Induced by a Hybrid Large Hepatitis B Surface Protein Composed of Two Viral Genotypes C and D
Takahiro Sanada (Japan)
PE-09
Impact of Alpha-Fetoprotein Expression on Interferon Pathways and VEGFA in Hepatocellular Carcinoma Microenvironment after Hepatitis C Virus Eradication
Katsuya Nagaoka (Japan)

ABSTRACT PRESENTATION

How to Prepare the Oral Presentation

  • For Oral Presentation, presenting authors use PowerPoint slides to accompany their oral presentation.
  • All presenters will participate in a question and answer session after their presentations.
  • Presentation size: Widescreen 16:9
  • The length of presentation: Total 15 minutes (12 minutes of presentation & 3 minutes of question and answer session)
  • Presentation language: English

How to Prepare Poster Exhibition

  • Please prepare a poster and the size of poster should be smaller than 90 cm wide x 150 cm high.
  • Posters must be readable by viewers 1-2 meters away.
  • The message should be clear and understandable without oral explanation.
  • The poster title, author(s)’s name(s), and affiliation(s) should appear at the top.
  • Contents should be in the order of abstract.
  • Each poster should be placed on the numbered board assigned to each presenter.
  • Posters should be brought to the meeting and not mailed, as the organizing committee cannot be responsible for loss or mishandling.
  • Presenters are responsible for posting and removing their own materials.
  • Handouts are encouraged for participants wishing to receive more information about your poster and research.
  • Note that landscape posters or larger posters will not fit on the poster display boards and therefore, cannot be mounted.
  • Poster Mounting & Removal

Mount: April 27, 2024, 08:30-09:30

Removal: April 28, 2024, 10:00-11:00

VENUE

  • Group Tour (16:00, April 26, 2024)

    Venue: Changgyeonggung Palace Please gather in front of the ticket office by 16:00 PM, and please do not purchase tickets. We will move together for the palace tour after we check attendance. After the tour, we will guide you to the welcome reception venue.

  • Welcome Reception (18:30, April 26, 2024)

    Venue: Lee Kun-Hee Auditorium (2F), Cancer Research Institute, Seoul National University Hospital

  • Symposium Venue (April 27-28, 2024)

    Venue: Woo Duck Yoon Duck Byung Hall (1F), Biomedical Research Institute, Seoul National University Hospital

  • Main Dinner-Social Hour (18:30, April 27, 2024)

    Venue: Seoulgaon (Sejong Art Center)
    We will provide transportation for all participants to the dinner venue. Please utilize the provided coach service (round trip).

Orakai Daehakro Hotel

180, Yulgok-ro, Jongno-gu, Seoul / TEL. +82-2-6353-7700

Mayplace Seoul Dongdaemun

179, Yulgok-ro, Jongno-gu, Seoul / TEL. +82-2-742-8080

AIRPORT(BUS & SUBWAY)

1. Airport Bus (From Incheon Int'l Airport)

Bus Number #6011 [Route: Incheon Int'l Airport → Seoul National University Hospital (Changgyeonggung)]
Bus Stop Incheon Airport Passenger Terminal 1, 1st floor 5B, Terminal 2, Basement 1 floor, No. 31
Route Map

Bus Information

Bus No. Intervals Traveling Time Fare Destination
#6011 20 - 30 min.
(05:25~22:55)		 70 min. KRW 17,000 Seoul National University Hospital
(Changgyeonggung)

2. City Bus (From Gimpo Int'l Airport)

You can take City Bus No. 601 that gets you off at Seoul National University Hospital. It will take about 80 minutes. Please check more information below.

Bus Boarding Area

Bus Information

Bus No. Platforms Intervals Traveling Time Fare Destination
#601 (City Bus) 1 Floor / No. 4 6 - 10 min.
(04:00~
23:10)		 80 min. KRW 1,500 Seoul National University Hospital
(Changgyeonggung)

3. Subway

From Gimpo Airport 5Gimpo Int’l Airport Station. Line No.5 → 4Dongdaemun Stadium Station.
(Transfer Line No.4) → Hyehwa Station Exit. 3
From Incheon International Airport Incheon Rapid Transit → 5Gimpo Int’l Airport Station. Line No.5 → 4Dongdaemun Stadium Station.(Transfer Line No.4) → Hyehwa Station Exit. 3

CAR(NAVIGATION SEARCH)

Title Search Seoul National University Hospital (서울대학교병원)
Address Search 101 DAEHAK-RO JONGNO-GU, SEOUL (서울시 종로구 대학로 101, 연건동)

SUBWAY

From -Seoul Station 4Seoul Station Line No.4 → Hyehwa Station Exit. 3
From Seoul Express Bus Terminal 3Express Bus Terminal Line No.3 → 4Choongmuro Station. (Transfer Line No.4)
→ Hyehwa Station Exit. 3
From Seoul Nambu Terminal 3Nambu Bus Terminal Line No.3 → 4Choongmuro Station. (Transfer Line No.4)
→ Hyehwa Station Exit. 3
From Dongseoul Bus Terminal 2Gangbyeon Station. Line No.2 → 4Dongdaemun Stadium Station.(Transfer Line No.4)
→ Hyehwa Station Exit. 3
From Sangbong Bus Terminal 7Sangbong Station. Line No.7 → 5Gunja Station.(Transfer Line No.5) → 4Dongdaemun Stadium Station. (Transfer Line No.4) → Hyehwa Station Exit. 3
From Gimpo Airport 5Gimpo Int’l Airport Station. Line No.5 → 4Dongdaemun Stadium Station.(Transfer Line No.4) → Hyehwa Station Exit. 3

BUS

Changkyunggung down Platform (#A) Blue100, 102, 104, 106, 107, 108, 140, 143, 149, 150, 151, 160, 162, 171, 172, 272, 301, 710
Airport6011 (Tour Bus : 90S)
Changkyunggung up Platform (#B) Blue151, 171, 172, 272, 601
Daehangno Hyehwa Station Exit. 3
A down Platform (#C)		 Blue109, 273, 601, N16
Green2112, Jongro 07, Jongro 08, Jongro 12 (around Hospital)
Daehangno Hyehwa Station Exit. 3
A up Platform (#D)		 Blue100, 102, 104, 106, 107, 108, 109, 140, 143, 150, 160, 162, 273, 301, 710, N16
Green2112, Jongro 07, Jongro 08 (Tour Bus : 90S)